Bioactive Small Molecules
Cayman Chemical CALP3 (trifluoroacetate salt), Purity: ≥98%, 5 mg
A calcium-like peptide; truncated version of CALP2; inhibits calcium influx through glutamate receptor channels in cultured rat neocortical neurons (IC50 = 37.25 µM); inhibits excitatory cytotoxicity (IC50 = 50.97 µM) and apoptosis (IC50 = 33.41 µM)
Cayman Chemical JNJ-10181457 (hydrochloride), Purity: ≥98%, CAS: 544707-20-2, 1 mg
A histamine H3 receptor antagonist (Kis = 1.17 and 7.08 nM for human and rat receptors, respectively); increases extracellular norepinephrine and acetylcholine levels in the frontal cortex of rats at 10 mg/kg; reduces the number of cataplectic attacks and time spent in cataplexy in familial narcoleptic Dobermans at 1.25-10 mg/kg; decreases the time spent in the open areas of the elevated zero maze in mice at 10 mg/kg, as well as increases locomotor activity in an open field test; inhibits LPS-induced increases in time spent immobile in the tail suspension test in mice.
TARGETMOL CHEMICALS INC FIDEXABAN 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Fidexaban (CI1031) is a novel potent selective and orally active factor Xa inhibitor that has demonstrated antithrombotic activity in a variety of assayspurity: 99%
Cayman Chemical TRO 19622, Purity: ≥95% (mixture of isomers), CAS: 22033-87-0, 100 mg
A mitochondrial-targeted neuroprotective agent; binds to and inhibits mPTP opening; prevents arachidonic acid-induced mPTP opening in HeLa cells at 10 µM; promotes survival of motor neurons in vitro in the absence of neurotrophic factors (EC50 = 3.2 µM); promotes survival of motor neurons in vivo in a neonatal rat model of facial nerve axotomy at 100 mg/kg per day; delays onset of motor deficits and extends survival in the SOD1G93A transgenic model of ALS; increases the latency to paw withdrawal in a mechanical hyperalgesia test in rat models of streptozotocin-induced diabetic and vincristine-induced neuropathic pain at 30 and 100 mg/kg
STEMCELL Technologies JAK Inhibitor I, Size: 1 mg
Janus Associated Kinase (JAK) Inhibitor I is a pyridine-containing tetracycle that disrupts JAK activity by interacting with the ATP binding domain. This inhibitor inhibits mouse JAK3 with Ki = 5 nM, JAK family members TYK2 and JAK2 with IC50 = 1 nM, and mouse JAK1 with IC50 = 15 nM, while showing weaker inhibition of other kinases (Thompson et al.). REPROGRAMMING· Inhibits the generation of mouse induced pluripotent stem cells (Efe et al.; Kim et al.).IMMUNOLOGY· Inhibits anti-viral response associated with JAK/STAT pathway activation (Xu et al.).
Apexbio Technology LLC TW-37, 10mg. Cas: 877877-35-5 MFCD: MFCD17010275. Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1
TW-37 is a potent small-molecule inhibitor of BCL-2 (Ki = 290 nmol/L), which attenuates BCL-2 activation and inhibits multiple BCL-2 family members including BCL-XL (Ki = 1,110 nmol/L) and MCL-1 (Ki = 260 nmol/L). Other sizes are available. Please inqury us for quote.
Medchemexpress LLC Endo-BCN-PEG4-val-cit-pab-mmae | 2762519-08-2 | 98.8% | 1546.93 | C80H127N11O19 | 5 MG
endo-BCN-PEG4-val-cit-pab-mmae is a cleavable antibody-drug conjugate (ADC) linker conjugated to monomethyl auristatin E (MMAE). It contains a bicyclo[6.1.0]non-4-yn (BCN) click handle and a four-unit polyethylene glycol (PEG4) spacer, and uses a Val-Cit-PAB dipeptide self-immolative linker for enzymatic (cathepsin) release of the payload. The material is supplied as a white to off-white solid and is unstable in solution; freshly prepare solutions.
- Cleavable Val-Cit-PAB dipeptide linker for enzymatic release.
- BCN handle enables strain-promoted alkyne-azide cycloaddition (SPAAC).
- PEG4 spacer increases hydrophilicity and solubility.
- Suitable for synthesizing antibody-drug conjugates and linker-drug studies.
- Supplied as a white to off-white solid; unstable in solution - prepare fresh.
Apexbio Technology LLC SU11274, 5mg. Cas: 658084-23-2 MFCD: MFCD08276928. C-Met inhibitor,potent and selective
SU11274 is a potent and selective inhibitor of Met kinase with IC50 value of 10nM [1]. Other sizes are available. Please inqury us for quote.
Cayman Chemical CAY10766, Purity: ≥98%, CAS: 2739990-96-4, 10 mg
An antiviral compound; inhibits entry of influenza virus-like particles pseutotyped with HA from H5N1 influenza A virus into A549 cells (EC50 = 0.24 µM); reduces H1N1 and H5N1 influenza A viral titers in infected MDCK cells at 1 µM; exhibits synergy with oseltamivir carboxylate in MDCK cells infected with the influenza A reporter PR8-NS1-Gluc virus
TARGETMOL CHEMICALS INC OXYRESVERATROL 500MG
Also available in 50 mg 100 mg 1000 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models as toxicity to glia could be beneficial by inhibiting reactive gliosis. 3. Oxyresveratrol (trans-Oxyresveratrol) has antioxidant activity can reduce neuronal oxidative damage and protect hepatocytes against oxidative stress and mitochondrial dysfunction which may be associated with activation of Nrf2. purity: 99%
Medchemexpress LLC Bis-ANS (dipotassium) | 65664-81-5 | 98.2% | 1 MG
Bis-ANS dipotassium is a fluorescent probe for hydrophobic proteins. It binds to tubulin with a Kd of 2 μM. It is also a potent biphasic modulator of protein liquid-liquid phase separation (LLPS), promoting LLPS at low concentrations and suppressing it at high concentrations. This compound has been utilized to probe exposed hydrophobic patches in proteins, monitor protein aggregate formation, and modulates the liquid-liquid phase separation of TDP-43 low complexity domain (LCD).
- Fluorescent probe for hydrophobic proteins
- Binds to tubulin with a Kd of 2 μM
- Potent biphasic modulator of protein liquid-liquid phase separation (LLPS)
- Promotes LLPS at low concentrations
- Suppresses LLPS at high concentrations
- Used to probe exposed hydrophobic patches in proteins
- Monitors protein aggregate formation
- Modulates the liquid-liquid phase separation of TDP-43 low complexity domain (LCD)
Cayman Chemical AZD 0865, Purity: ≥98%, CAS: 248919-64-4, 1 mg
An H+/K+-ATPase inhibitor (Ki = 46 nM); inhibits histamine- or dibutyryrl-cAMP-induced acid production in isolated rabbit gastric glands (IC50s = 0.28 and 0.26 µM, respectively)
Medchemexpress LLC 1αH,5αH-Guaia-6-ene-4β,10β-diol | 2013537-81-8 | 5 MG
1αH,5αH-Guaia-6-ene-4β,10β-diol is a sesquiterpenoid derivative identified from *Alisma orientale*. This compound has demonstrated anti-cancer activities.
- Sesquiterpenoid derivative identified from *Alisma orientale*
- Has anti-cancer activities
- Active against H460, MCF-7, and PC-7 cell lines with IC50 values of 56.7 μM, 76.7 μM, and 59.0 μM, respectively
Apexbio Technology LLC PIK-75 HCl 372196-77-5 50mg
PIK-75 HCl (CAS 372196-77-5) is a potent selective inhibitor of the phosphoinositide 3-kinase (PI3K) p110 isoform exhibiting an IC50 of 5 8 nM In acute myeloid leukemia cells PIK-75 disrupts PI3K signaling by targeting p110 leading to loss of interaction between Bcl-xL and Bak and transient reduction of Cdk7/9 which diminishes Mcl-1 and enhances pro-apoptotic responses In endothelial and monocytic cells PIK-75 suppresses downstream PI3K pathways including AKT phosphorylation IKK activation and NF- B transcription thereby reducing expression of adhesion molecules and production of TNF- and IL-6 Additional studies report modulatory effects on CD38 expression in airway smooth muscle cells and promotion of insulin secretion in pancreatic -cells In vivo PIK-75 attenuates experimental colitis and inflammatory responses supporting its utility in studies of PI3K signaling apoptosis and inflammation
Medchemexpress LLC BRD5529 10mM 1mL | 1358488-78-4 | 1 ML
Small-molecule CARD9-TRIM62 protein-protein interaction (PPI) inhibitor supplied for laboratory research and provided as a 10 mM solution in DMSO or as solid material. The compound has a molecular weight of 465.54 g/mol and is supplied at high purity for in vitro studies. Not for human therapeutic or diagnostic use.
- Effective CARD9-TRIM62 PPI inhibitor with reported IC50 around 8.6 μM.
- Available as a 10 mM solution in DMSO and in multiple solid vial sizes.
- High purity (≈98.9%) suitable for biochemical and cellular assays.
- Molecular weight 465.54 g/mol for calculation of dosing and concentrations.
- Storage recommendations provided for powder and solution to preserve stability.
- Intended for research use only; not for clinical or diagnostic applications.